Longevity by Design
Longevity by Design is your go-to podcast for unlocking the secrets to a longer, healthier life. Hosted by Dr. Gil Blander, a renowned scientist and entrepreneur in the fields of aging, nutrition, and personalized health, this show dives into cutting-edge research and practical strategies for optimizing your healthspan and lifespan.
In each episode, Dr. Blander sits down with leading longevity and health scientists to explore how we can live better, longer lives. From unpacking complex scientific concepts to sharing the latest advancements in aging research, Longevity by Design offers science-backed insights and actionable advice to help you add years to your life—and life to your years.
Dr. Blander is the founder and Chief Scientific Officer of InsideTracker, a healthspan company that leverages blood tests, DNA analysis, fitness tracker data, and other biomarkers to deliver personalized health recommendations. With a Ph.D. in biology from the Weizmann Institute of Science and postdoctoral research at MIT, Dr. Blander brings decades of expertise and passion to every conversation.
Tune in to Longevity by Design and discover how to live a longer, healthier, and more vibrant life.
Longevity by Design
How to Improve Your Healthspan Using DNA Insights with Dr. Bartek Nogal
In this episode of Longevity By Design, Dr. Gil Blander interviews Dr. Bartek Nogal about genetic predispositions to conditions of aging. This episode goes deep into explaining how to improve your healthspan using DNA insights. Dr. Blander and Dr. Nogal talk about bone mineral density, epigenetic age acceleration, cognitive decline, risk of elevated ApoB, grip strength, and more. Knowing your genetic predispositions to certain traits can help you fine tune your wellness plan, and Dr. Nogel and Dr. Blander explain how to do so in this episode.
Episode timestamps:
- Introduction: (0:00–3:40)
- What led Dr. Nogel to become a scientist (3:40–5:32)
- Moving from academia to InsideTracker (5:32–7:28)
- What is DNA? (7:28–9:12)
- How similar is DNA across animal species? (9:12–10:05)
- Single Nucleotide Polymorphisms (SNPs) (10:05–14:10)
- How polygenic scores are calculated (14:10–17:25)
- Defining heritability (17:25–22:53)
- ApoB is highly heritable (22:53–24:24)
- Why you should measure blood and DNA together (24:24–31:50)
- Science behind the new polygenic scores added to InsideTracker (31:50–38:20)
- How many SNPs are in the ApoB score? (38:20–41:20)
- Visceral fat (41:20–45:07)
- Age related muscle weakness (45:07–49:10)
- Bone mineral density (49:10–51:45)
- Chronotype—genetic predisposition to morningness (51:45–55:37)
- Lifespan DNA score (55:37–60:10)
- Epigenetic age acceleration (60:10–1:06:40)
- Cognitive aging (1:06:40–1:08:20)
- Age at menopause (1:08:20–1:10:40)
- Top tip for healthspan: (1:10:40–end)
Listen to all episodes of Longevity by Design at https://info.insidetracker.com/longevitybydesign
