Writer/Director Coralie Fargeat's Cannes-winning body-horror blitz THE SUBSTANCE features Demi Moore as an aging star who turns to a mystery drug in hopes of becoming a better, younger version of herself. Fargeat tells host Rico Gagliano about casting Moore, why blood and guts are great metaphors, and the pain of makeup removal.

THE SUBSTANCE comes to theaters in the US, UK, Latin America, Germany, Canada and Netherlands on September 19 & 20. Visit trythesubstance.com for showtimes and tickets.

To stream some of the films we've covered on the podcast, check out the collection Featured on the MUBI Podcast. Availability of films varies depending on your country.

MUBI is a global streaming service, production company and film distributor dedicated to elevating great cinema. MUBI makes, acquires, curates, and champions extraordinary films, connecting them to audiences all over the world. A place to discover ambitious new films and singular voices, from iconic directors to emerging auteurs. Each carefully chosen by MUBI’s curators.