Episode 154: What is Anabolic Resistance and How Does It Affect… Aging Well?

Anabolic resistance, a phenomenon marked by reduced muscle protein synthesis and impaired muscle maintenance, is a significant concern in aging populations. In this episode, Dr. Armstrong and Corbin Bruton discuss anabolic resistance and its impact on healthy aging.

They explore the factors contributing to anabolic resistance, ranging from age-related declines in muscle protein synthesis to alterations in cellular signaling pathways. Despite its prevalence, the hosts challenge the notion that anabolic resistance is an inevitable consequence of aging, emphasizing the role of lifestyle interventions in mitigating its effects. Through discussions on resistance training, protein intake optimization, and other strategies, they highlight actionable steps individuals can take to combat anabolic resistance, maintain muscle health, and… age well.

Articles:

Aragon, A. A., Tipton, K. D., & Schoenfeld, B. J. (2023). Age-related muscle anabolic resistance: inevitable or preventable? Nutrition reviews, 81(4), 441-454. https://doi.org/10.1093/nutrit/nuac062

Breen, L., & Phillips, S. M. (2011) Skeletal muscle protein metabolism in the elderly: Interventions to counteract the 'anabolic resistance' of ageing. Nutrition & Metabolism, 8: 68. https://doi.org/10.1186/1743-7075-8-68

Burd, N. A., Gorissen, S. H., & van Loon, L. J. C. (2013). Anabolic Resistance of Muscle Protein Synthesis with Aging. Exercise and Sport Sciences Reviews, 41(3): 169-173.  https://doi.org/10.1097/JES.0b013e318292f3d5

Burd, N. A., Wall, B. T., & van Loon, L. J. C. (2012). The curious case of anabolic resistance: old wives’ tales or new fables? Journal of Applied Physiology., 112(7), 1233–1235. https://doi.org/10.1152/japplphysiol.01343.2011

Haran, P. H., Rivas, D. A., & Fielding, R. A. (2012). Role and potential mechanisms of anabolic resistance in sarcopenia. Journal of Cachexia, Sarcopenia and Muscle, 3(3), 157-162. https://doi.org/10.1007/s13539-012-0068-4

Morton, R. W., Traylor, D. A., Weijs, P. J. M., & Phillips, S. M. (2018). Defining anabolic resistance: implications for delivery of clinical care nutrition. Current Opinion in Critical Care, 24(2): 124-130. https://doi.org/10.1097/MCC.0000000000000488

Paulussen, K. J., McKenna, C. F., Beals, J. W., Wilund, K. R., Salvador, A. F., & Burd, N. A. (2021). Anabolic resistance of muscle protein turnover comes in various shapes and sizes. Frontiers in nutrition, 8, 615849.  https://doi.org/10.3389/fnut.2021.615849

Rennie M. J. (2009). Anabolic resistance: the effects of aging, sexual dimorphism, and immobilization on human muscle protei

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