Medical Discovery News
Science permeates everyday life. Yet the understanding of advances in biomedical science is limited at best. Few people make the connection that biomedical science is medicine and that biomedical scientists are working today for the medicine of tomorrow. Our weekly five-hundred-word newspaper column (http://www.illuminascicom.com/) and two-minute radio show provide insights into a broad range of biomedical science topics. Medical Discovery News is dedicated to explaining discoveries in biomedical research and their promise for the future of medicine. Each release is designed to stimulate listeners to think, question and appreciate how science affects their health as well as that of the rest of the world. We also delve into significant biomedical discoveries and portray how science (or the lack of it) has impacted health throughout history.
Medical Discovery News
Calcineurin Inhibitors and Reduced Incidence of Dementia
900 - Calcineurin Receptors and Reduced Incidence of Dementia
Welcome to Medical Discovery News. I’m Dr Norbert Herzog.
And I’m Dr. David Niesel
Sometimes the biggest scientific discoveries are made when ideas from different fields collide, especially when they’re not even working on the same question. We call this, “collision science.”
At our university, a neuroscientist studying dementia and a transplant surgeon were having a casual conversation when they realized that transplant patients have lower rates of dementia.
They thought it could be the drugs these patients take to keep their immune systems from “rejecting” the new organ.
One of those drugs blocks a protein called calcineurin or CN. That’s because CN activates the immune system, but it’s also involved in plaque formation in the brain that contributes to Alzheimer’s disease.
In lab experiments with rats that have problems forming memories, when CN is blocked from acting, the animals recover their memory function.
So, researchers reviewed the health records of more than two hundred million patients to pull fifty thousand control patients sixty-five and older. They then pulled nearly eighty thousand transplant patients of the same age bracket and compared the two groups.
These transplant patients were all treated with CN inhibitors and their hunch was right. They all had lower rates of dementia.
There’s more reason to be optimistic. All three drugs have been approved by the FDA for human use. So, there’s a much shorter runway and cost to human trials.
This example of collision science shows how innovative we can be when we collaborate to solve some of our biggest challenges.
We are Drs. David Niesel and Norbert Herzog, at UTMB and Quinnipiac University, where biomedical discoveries shape the future of medicine. For much more and our disclaimer go to medicaldiscoverynews.com or subscribe to our podcast. Sign up for expanded print episodes at www.illuminascicom.com