Dr. Journal Club
Dr. Journal Club
Osteoporosis Treatment Options: A Super Speedy Review
Unlock the secrets to effective osteoporosis treatment in this super speedy review from the Dr Journal Club podcast. Dr. Joshua Goldenberg highlights key medications from a recent BMJ systematic review and network meta-analysis. Discover why PTH agonists are the most effective for preventing clinical fractures in postmenopausal women and see how other medications compare.
With over 80,000 women in 69 randomized controlled trials, the study offers crucial insights into the efficacy and safety of various osteoporosis medications, with no significant harm outcomes reported. Whether you're a healthcare professional or a concerned family member, this episode is packed with valuable information. Don't miss the basic and in-depth versions of the review available on our platform!
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Welcome to the Dr Journal Club podcast, the show that goes under the hood of evidence-based integrative medicine. We review recent research articles, interview evidence-based medicine thought leaders and discuss the challenges and opportunities of integrating evidence-based and integrative medicine. Continue your learning after the show at www. d rjournalclub. com.
Dr. Joshua Goldenberg:Please bear in mind that this is for educational and entertainment purposes only. Talk to your doctor before making any medical decisions, changes etc. Everything we're talking about that's to teach you guys stuff and have fun. We are not your doctors. Also, we would love to answer your specific questions on drjournalclubcom. You can post questions and comments for specific videos, but go ahead and email us directly at josh at drjournalclub. com. That's josh at drjournalclub. com. Send us your listener questions and we will discuss it on our pod.
Dr. Joshua Goldenberg:Hello and welcome to another super speedy summary. This is your host, dr Joshua Goldenberg. Today we're going to talk about what works for osteoporosis. This was a very recent systematic review and network meta-analysis in my favorite journal, the BMJ. Dr Adam Sadowski goes into detailed review of the study in the basic level and in-depth level version of this study, but today we're going to just cover the highlights here.
Dr. Joshua Goldenberg:So osteoporosis is common. Unfortunately, fractures are extremely concerning to patients and their families. People who are newly diagnosed are often terrified about you know are they going to break their backs, are they going to be able to pick up their grandchildren, etc. Etc. Things that have just takes over the psyche of those newly diagnosed and it's going to be quite concerning for patients and their fam. And alongside these concerns, the number of medications for osteoporosis has expanded recently and randomized controlled trials have proliferated. Now, when you have multiple randomized controlled trials that use you know, some use placebos, some use active comparators etc it becomes really clear if you stack them against each other which ones are the best, and that's really where network meta-analyses thrive. So the question is you know what are the most effective and that's really where network meta-analyses thrive. So the question is you know what are the most effective and safe osteoporosis medications to prevent fractures, which is the most clinically important outcome in those with osteoporosis. So, like I said, this was a network meta-analysis. They had 69 randomized controlled trials, over 80,000 patients, and these were all in postmenopausal women and they took any study that used any type of OP osteoporosis medication in any comparator, including placebo. And the beautiful thing about network meta-analyses is it can kind of create this network and tell you well, if this intervention would have been studied against that intervention, what is the overall effect. And they're able to say that through these shared comparators. And if you want to learn more about that, we've got a bunch of videos on this in Dr Journal Club and they were looking primarily at all fractures, clinical fractures as well as secondary outcomes, including specific fractures such as vertebral fractures, as well as harm outcomes. So what did they find? So, for clinical fractures, they basically found that the bisphosphonates, so everything kind of worked. It was all more effective when compared to placebo, but the PTH agonists were going to be the most effective there. As far as vertebral fractures, which is what most people are very concerned about, again, all were effective compared to placebo, but the bisphosphonates performed less or least well, I guess, compared to the other intervention classes, and no harm outcomes were seen. So if you'd like to see more detail on this study, go ahead and watch the basic and in-depth level versions done by the amazing Dr Adam Sadowski. See you next time.
Dr. Joshua Goldenberg:If you enjoy this podcast, chances are that one of your colleagues and friends probably would as well. Please do us a favor and let them know about the podcast and, if you have a little bit of extra time, even just a few seconds, if you could rate us and review us on Apple Podcast or any other distributor. It would be greatly appreciated. It would mean a lot to us and help get the word out to other people that would really enjoy our content. Thank you, hey y'all.
Dr. Joshua Goldenberg:This is Josh. You know we talked about some really interesting stuff today. I think one of the things we're going to do that's relevant. There is a course we have on Dr Journal Club called the EBM Boot Camp. That's really meant for clinicians to sort of help them understand how to critically evaluate the literature, etc. Cetera. Some of the things that we've been talking about today. Go ahead and check out the show notes link. We're going to link to it directly. I think it might be of interest. Don't forget to follow us on social and interact with us on social media at Dr Journal Club Dr Journal Club on Twitter, we're on Facebook, we're on LinkedIn, et cetera, et cetera. So please reach out to us. We always love to talk to our fans and our listeners. If you have any specific questions you'd like to ask us about research, evidence, being a clinician, et cetera, don't hesitate to ask. And then, of course, if you have any topics that you'd like us to cover on the pod, please let us know as well.
Introducer:Thank you for listening to the Doctor Journal Club podcast, the show that goes under the hood of evidence-based integrative medicine. We review recent research articles, interview evidence-based medicine thought leaders and discuss the challenges and opportunities of integrating evidence-based and integrative medicine. Be sure to visit www. drjournalclub. com to learn more.