Working Up ALKP Dominant Liver Conditions: Part 1 with Dr. Tristan Weinkle

Join us as we meet at the rounds table with Dr. Tristan Weinkle, DVM, DACVIM board certified in small animal internal medicine (SAIM), private practice clinician, and owner/founder of Sonant Veterinary Imaging and Education to talk about the mysteries of the liver, focusing on diseases that influence ALKP dominant enzymology. This isn’t just vacuolar hepatopathy and Cushing’s, we’ll be delving into the other disorders that influence liver enzyme activity like dyslipidemia, chronic inflammatory disease, and breed specific concerns. Whether you're a seasoned veterinarian, a passionate pet owner, or just curious about the impacts of the hepatic health on general wellbeing in our companion animals, grab your gear and join us as we navigate through the landscapes of liver disease in small animals with the incredible Dr. Tristan Weinkle. This podcast is one you won’t want to miss.

Episode Resources and References:

Please visit our website for Dr. Weinkle's accompanying slides

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De Marco V, Noronha KSM, Casado TC, Nakandakare ER, Florio JC, Santos EZ, Gilor C.
Therapy of Canine Hyperlipidemia with Bezafibrate. J Vet Intern Med. 2017 May;31(3):717-722. doi: 10.1111/jvim.14701. Epub 2017 Apr 6. PMID: 28382723; PMCID: PMC5435059.

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Evaluation of canine hepatic masses by use of triphasic computed tomography and B-mode, color flow, power, and pulsed-wave Doppler ultrasonography and correlation with histopathologic classification. Am J Vet Res. 2017 Nov;78(11):1273-1283. doi:
10.2460/ajvr.78.11.1273. PMID: 29076364.

Hall-Fonte DL, Center SA, McDonough SP, Peters-Kennedy J, Trotter TS, Lucy JM, Berger E, Byers C, Cummings CG, Burke E, Stegemen J, Pintar J, Kantrowitz L, Sharpe K, Weinkle T. Hepatocutaneous syndrome in Shih Tzus: 31 cases (1996-2014). J Am Vet Med Assoc. 2016 Apr 1;248(7):802-13. doi: 10.2460/javma.248.7.802. PMID: 27003022.

Kim C, Loftus JP, Huson HJ. Low alanine aminotransferase activity gene variant in a Siberian Husky with copper-associated hepatopathy. BMC Vet Res. 2023 Aug 7;19(1):111. doi: 10.1186/s12917-023-03681-6. PMID: 37550687; PMCID: PMC10405506. Miceli DD, Guevara JM, Ferraris S, Pignataro OP, Gallelli MF. Therapy for feline secondary hypertriglyceridemia with fenofibrate. J Feline Med Surg. 2022 Aug;24(8):e251-e257. doi: 10.1177/1098612X221104066. Epub 2022 Jun 17. PMID: 35713593.

Munro MJL, Hulsebosch SE, Marks SL, Gilor C. Efficacy of a micronized, nanocrystal
fenofibrate formulation in treatment of hyperlipidemia in dogs. J Vet Intern Med. 2021
Jul;35(4):1733-1742. doi: 10.1111/jvim.16190. Epub 2021 Jun 6. PMID: 34096101; PMCID: PMC8295657.

Sepesy LM, Center SA, Randolph JF, Warner KL, Erb HN. Vacuolar hepatopathy in dogs: 336 cases (1993-2005). J Am Vet Med Assoc. 2006 Jul 15;229(2):246-52. doi:
10.2460/javma.229.2.246. PMID: 16842046.

Steiner JM, Lainesse C, Noshiro Y, Domen Y, Sedlacek H, Bienhoff SE, Doucette KP, Bledsoe DL, Shikama H. Fuzapladib in a randomized controlled multicenter masked study in dogs with presumptive acute onset pancreatitis. J Vet Intern Med. 2023 Nov-Dec;37(6):2084-2092. doi: 10.1111/jvim.16897. Epub 2023 Oct 9. PMID: 37811705; PMCID: PMC10658511.

Xenoulis PG, Cammarata PJ, Walzem RL, Suchodolski JS, Steiner JM. Effect of a low-fat diet on serum triglyceride and cholesterol concentrations and lipoprotein profiles in Miniature Schnauzers with hypertrig