Foundational Skills in Life Sciences

30. Positive controls in another experiment by Nobel Laureates (mini-series: reading-21)

Dr. Synaptologica Episode 30

We will keep analyzing the specific positive controls that the Nobel Laureates used in their milestone article 1 that led to the Nobel Prize. We will examine the four positive controls in the third figure of this paper, and in other figures as well. Those positive controls did not necessarily show positive responses in multiple figures. We will observe that positive controls can show variable behaviors in a paper. We will also discuss how a modified definition of positive controls will be helpful for understanding them.       

Here are the links to the Milestone Article 1  (Immunity, 2005) by the Laureates, Dr. Katalin Karikó & Dr. Drew Weissman of the Nobel Prize in Physiology or Medicine 2023.     

  • DOI: https://doi.org/10.1016/j.immuni.2005.06.008
  • PDF: https://www.cell.com/immunity/pdf/S1074-7613(05)00211-6.pdf
  • PubMed: https://pubmed.ncbi.nlm.nih.gov/16111635/

   
(My email is active. But my website is under construction. Please wait for a while. Thank you for the patience!)