Curious about cannabis and migraines? In this episode, we explore the intriguing connection between the two. Discover how cannabis, historically used for headache relief, is making a comeback in medical circles despite legal hurdles. We dive into the endocannabinoid system, THC, CBD, and their potential impacts on migraine pathways. Learn about the latest research, including a groundbreaking clinical trial published in Neurology, and what it reveals about cannabis as a treatment for migraine pain. Tune in to uncover the science, history, and future possibilities of using cannabis to combat migraines.
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References:
Leimuranta, P., Khiroug, L., & Giniatullin, R. (2018). Emerging role of (endo) cannabinoids in migraine. Frontiers in Pharmacology, 9, 420. https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2018.00420/full
Mechtler, L. L., Gengo, F. M., & Bargnes, V. H. (2021). Cannabis and migraine: it’s complicated. Current Pain and Headache Reports, 25, 1-13. https://link.springer.com/article/10.1007/s11916-020-00931-2
Rhyne, D. N., Anderson, S. L., Gedde, M., & Borgelt, L. M. (2016). Effects of medical marijuana on migraine headache frequency in an adult population. Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, 36(5), 505-510. https://accpjournals.onlinelibrary.wiley.com/doi/full/10.1002/phar.1673
Russo, E. (1998). Cannabisfor migraine treatment: the once and future prescription? An historical and scientific review. Pain, 76(1), 3-8. https://journals.lww.com/pain/abstract/1998/05000/cannabisfor_migraine_treatment__the_once_and.2.aspx
Russo, E. B. (2016). Clinical endocannabinoid deficiency reconsidered: current research supports the theory in migraine, fibromyalgia, irritable bowel, and other treatment-resistant syndromes. Cannabis and cannabinoid research, 1(1), 154-165. https://www.liebertpub.com/doi/full/10.1089/can.2016.0009
Schuster, N., Wallace, M., Buse, D., Marcotte, T., Lee, E., Liu, L., & Sexton, M. (2024, April). Vaporized Cannabis versus Placebo for Acute Migraine: A Randomized Controlled Trial (S22. 010). In Neurology (Vol. 102, No. 17_supplement_1, p. 3105). Hagerstown, MD: Lippincott Williams & Wilkins. https://www.neurology.org/doi/abs/10.1212/WNL.0000000000204925 (preprint available at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10889030/)
Sexton, M., Cuttler, C., Finnell, J. S., & Mischley, L. K. (2016). A cross-sectional survey of medical cannabis users: patterns of use and perceived efficacy. Cannabis and cannabinoid research, 1(1), 131-138. https://www.liebertpub.com/doi/full/10.1089/can.2016.0007
