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Mind & Matter

Nick Jikomes

Whether food, drugs or ideas, what you consume influences who you become. Learn directly from the best scientists & thinkers alive today about how your mind-body reacts to what you feed it.

The weekly M&M podcast features conversations with the most interesting scientists, thinkers, and technology entrepreneurs alive today.


Not medical advice.

At M&M, we are interested in trying to figure out how things work, not affirming our existing beliefs. We prefer consulting primary rather than secondary sources and independent rather than institutional voices. If we encounter uncomfortable truths or the evidence suggests unfashionable ideas may be valid, so be it.


As the host, my aim is to help you better understand how the body & mind work by curating & synthesizing information in a way that yields science-based insights that you can choose to use or disregard in your own life. Taking ownership of your health starts with taking ownership of your information diet.


I am motivated to connect the dots and distill general principles from what I learn, preferring to ask questions and play devil’s advocate to debating or incessantly pushing my own viewpoint.


My beliefs:


Sometimes modern discoveries teach us we must unlearn received wisdom. Other times, modern information overload & historical chauvinism cause us to forget ancient wisdom which stills applies. The framework for learning that I embody is inspired by three Ancient Greek maxims inscribed in the Temple of Apollo at Delphi:

  • “Γνῶθι σεαυτόν” (Know thyself)
  • “Μηδὲν ἄγαν” (Nothing in excess)
  • “Ἐγγύα πάρα δ Ἄτα” (Certainty brings insanity)
History of Diet & Food, Population Density & Social Stability, Psychological Pandemics, Physical & Mental Health in Civilizational Cycles | Rudyard Lynch | IS #2July 19, 2024
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Evolution: Natural Selection, Genetic Drift, Origin of Life, Cellular Complexity, Epigenetics | Michael Lynch | #166July 14, 2024
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PUFAs in Brain Health & Disease, Dietary Fats, Brain Lipids, Nutrition | Richard Bazinet | #165July 10, 2024
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Seed Oils, Chronic Disease, Diet & Religious Cults, Mainstream Medicine vs. Independent Research | Tucker Goodrich | IS #1June 30, 2024
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Dopamine, Reward, Motivation, Lateral Hypothalamus, Feeding Behavior & Eating Disorders | Melissa Sharpe | M&M #164June 26, 2024
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Anesthesia, Placebo Effects, Consciousness, Subjectivity, MDMA, Ketamine, Opioids, Psychedelics | Boris Heifets | M&M #163June 21, 2024
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Drugs, Addiction & Neuroplasticity: Psychedelics, MDMA, Opioids, Cocaine, Amphetamine (Adderall), Nicotine, Marijuana & Alcohol | Robert Malenka | #162June 16, 2024
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GLP-1, Weight Loss Drugs, Ozempic, Obesity, NMDA Receptors, Metabolism & Brain Health | Christoffer Clemmensen | #161June 12, 2024
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Diet, Hunting, Culture and Evolution of Paleolithic Humans & Hunter Gatherers | Eugene Morin | M&M #160June 01, 2024
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Neuroscience of Social Behavior, Pain, Empathy, Emotion, Brain Mechanisms of MDMA | Monique Smith | M&M #159May 23, 2024
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Ketosis & Ketogenic Diet: Brain & Mental Health, Metabolism, Diet & Exercise, Cancer, Diabetes | Dominic D'Agostino | #158May 16, 2024
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Preventative Medicine, Diet & Lifestyle vs. Pharmaceuticals in Health & Disease, Lies Taught in Medical Schools | Robert Lufkin | #157May 09, 2024
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Psychology of Stress, Resilience, Emotion & Child Development | Stephen Sideroff | #156May 03, 2024
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Cell Biology of Aging, Mitochondria, Metabolism, Autophagy & Stress | Andrew Dillin | #155April 29, 2024
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Evolution & Genetics of Human Diet, Metabolism, Disease Risk, Skin Color & Origins of Modern Europeans | Eske Willerslev | #154April 24, 2024
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Diet, Nutrition, Metabolic Psychiatry, Brain & Mental Health | Georgia Ede | #153April 19, 2024
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Plant Chemistry, Cannabinoids, Cannabis Terpenes & the Entourage Effect | Ryan Vandrey | #152April 12, 2024
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Aging, mTOR, Sirtuins, Rapamycin, Metformin, the Truth of Resveratrol & Longevity Supplements, David Sinclair & Anti-Aging Myths | Matt Kaeberlein | #151April 07, 2024
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Visual System, Visual Impairments & Cures, Amblyopia, Neuroplasticity, Critical Periods & Metaplasticity, Ketamine & Psychedelics | Mark Bear | #150April 03, 2024
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DNA & RNA Biology, mRNA Vaccines, Vaccine Contamination & Side Effects, Spike Protein, Ivermectin, Hop Latent Viroid | Kevin McKernan | #149March 30, 2024
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Dietary Protein, Muscle Growth, Resistance Training, Amino Acids, Plant vs. Animal Protein Sources, Anabolic Growth | Luc van Loon | #148March 27, 2024
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Ketamine: Opioid System, Sex Differences, S- vs. R- Isomers, Depression & Ultrasound Imaging Technology | Tommaso Di Ianni | #147March 22, 2024
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Photobiology, Sunlight, Firelight, Incandescent Bulbs vs. LEDs, Mitochondria, Melatonin, Sunscreen & the Optics of the Body | Scott Zimmerman | #146March 19, 2024
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Epigenetics, Hormones, Endocrine Disruptors, Microplastics, Xenoestrogens, Obesogens & Obesity, Inheritance of Acquired Characteristics | Bruce Blumberg | #145March 14, 2024
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Inflammation, Innate Immunity, Allergies & Allergens, Immune System Evolution, Fasting & Metabolism | Clare Bryant | #144March 10, 2024
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